Formation and significance of 6-methylthiopurine ribonucleotide as a metabolite of 6-mercaptopurine.
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منابع مشابه
A mechanism of resistance to 6-mercaptopurine: metabolism of hypoxanthine and 6-mercaptopurine by sensitive and resistant neoplasms.
Leukemia L1210 ascites tumor cells sensitive to inhibition by 6-mercaptopurine were observed to metabolize hypoxanthine-8-C14 and 6-mercaptopurine-S36 to ribonucleotide derivatives in vivo. Hypoxanthine-8-CH extensively labeled adenylic and guanylic acids of L1210 nucleic acids. Soluble enzyme preparations from L1210 ascites cells catalyzed the reactions of adenine, guanine, 8-azaguanine, hypox...
متن کاملSynergistic Effect of 6-Mercaptopurine and 6-Methylmercaptopurine Ribonucleoside on the Levels of Adenine Nucleotides of Sarcoma 180 Cells1
The synergistic antitumor action of 6-mercaptopurine (6-MP) and 6-methylmercaptopurine ribonucleoside (MMPR) is confirmed with Sarcoma 180 ascites cells. Striking decreases are seen in the adenine nucleotide concentrations in cells incubated for 1 hr with this drug combination, and lesser effects are seen on the guanine nucleotide concentrations. Still greater decreases in adenine nucleotide le...
متن کاملSynergistic effect of 6-mercaptopurine and 6-methylmercaptopurine ribonucleoside on the levels of adenine nucleotides of Sarcoma 180 cells.
The synergistic antitumor action of 6-mercaptopurine (6-MP) and 6-methylmercaptopurine ribonucleoside (MMPR) is confirmed with Sarcoma 180 ascites cells. Striking decreases are seen in the adenine nucleotide concentrations in cells incubated for 1 hr with this drug combination, and lesser effects are seen on the guanine nucleotide concentrations. Still greater decreases in adenine nucleotide le...
متن کاملToxicity Evaluation of 6-Mercaptopurine Using Accelerated Cytotoxicity Mechanism Screening (ACMS) techniques
6- Mercaptopurine (6-MP) is widely used in clinic as an immunosuppressive for treatment of acute lymphocytic leukemia, Crohn's disease, and ulcerative colitis with documented unpredictable hepatotoxicity. The potential molecular cytotoxic mechanisms of 6-MP against isolated rat hepatocytes were searched in this study using “Accelerated Cytotoxicity Mechanism Screening (ACMS)” techniques. The co...
متن کاملMMPR in combination with 6-mercaptopurine is effective in inducing remission in adults with acute myelogenous leukemia
MMPR2 is an adenosine analog with substantial antitumor activity in experimental systems (1 , 12). It is not cross resistant with 6-mercaptopurine; Le., it maintains its activity in Ll210 mouse leukemia and human cancer cells in culture, which are resistant to 6-mercaptopurine (2, 4). The biochem ical basis for this lack of cross-resistance has been established (1, 4, 14). Resistance to the thi...
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عنوان ژورنال:
- Cancer research
دوره 31 2 شماره
صفحات -
تاریخ انتشار 1971